Abstract:Objective To investigate the effects of Ruiyun procedure for hemorrhoids (RPH) combined with interlocking suture after external dissection on grade III mixed hemorrhoids.Methods The 120 patients with grade III mixed hemorrhoids admitted to Air Force Special Medical Center from April 2020 to June 2022 were selected and divided into two groups according to the admission time. The control group (admission time: from April 2020 to May 2021, n = 58) received RPH combined with external hemorrhoidectomy, and the observation group (admission time: from June 2020 to June 2022, n = 62) was treated with RPH for internal hemorrhoids combined with interlocking suture after external dissection. The surgical outcomes, severity of anal pain, bowel movement conditions, anal dynamic parameters, complications, and recurrence rates were compared between the two groups.Results The wound healing time and the length of hospital stay in the observation group were shorter than those in the control group (P < 0.05). There was no significant difference in the operative duration between the observation group and the control group (P > 0.05). The differences of the Visual Analogue Scale scores and the Fecal Incontinence Severity Index before and after the surgery in the observation group were higher than those in the control group (P < 0.05). The differences of the anal maximal contraction pressure, anal resting relaxation pressure and anal resting pressure before and after the surgery in the observation group were lower than those in the control group (P < 0.05). The differences of serum levels of epidermal growth factor and transforming growth factor-β before and after the surgery in the observation group were lower than those in the control group (P < 0.05). There was no significant difference in the overall complication rate between the observation group and the control group (P > 0.05). The recurrence rate in the observation group was lower than that in the control group (P < 0.05).Conclusions The treatment of grade III mixed hemorrhoids with RPH for internal hemorrhoids combined with interlocking suture after external dissection for external hemorrhoids demonstrates significant efficacy, effectively reducing anal pain, improving bowel movement conditions, enhancing anal dynamics, and lowering the recurrence rate.