不同运动处方对同型半胱氨酸影响的研究进展

Advances in the effects of different exercise prescriptions on homocysteine levels

摘要:

同型半胱氨酸（Hcy）是蛋氨酸代谢的重要中间产物，其表达升高不仅是高血压的独立危险因素，而且在导致心脑血管事件上具有显著的协同作用，使发病概率大幅增加。影响Hcy浓度的因素包括年龄、性别、遗传、饮食和体力活动。尽管体育锻炼被证明能降低心血管风险，但其对Hcy浓度的影响尚不明确，研究结果存在矛盾。前期研究表明，多数情况下剧烈运动会导致健康人群Hcy浓度升高，但轻度或中等强度运动通常会降低心血管疾病或神经系统疾病患者的Hcy水平。该研究旨在探讨不同运动对心脑血管人群等H型高血压患者Hcy浓度的影响，以期为制订个体化运动防治H型高血压提供新思路。

Abstract:

Homocysteine (Hcy) is an important intermediate in methionine metabolism. Elevated Hcy is not only an independent risk factor for hypertension but also significantly synergizes with hypertension in causing cardiovascular and cerebrovascular events, thereby greatly increasing their incidence rates. Factors influencing Hcy levels include age, sex, genetics, diet, and physical activity. Although physical exercise has been shown to reduce cardiovascular risks, its effect on Hcy levels remains unclear with conflicting research findings. Most previous studies suggest that intense exercise tends to elevate Hcy levels in healthy individuals, whereas mild to moderate exercise often lowers Hcy levels in patients with cardiovascular or neurological diseases. This review aims to discuss the effects of different types of exercise on Hcy levels in patients with H-type hypertension, providing novel insights for developing personalized exercise interventions for the prevention and management of H-type hypertension.