巨噬细胞糖代谢重编程在复发性流产中的研究进展

Research progress on macrophage glucose metabolism reprogramming in recurrent abortion

摘要:

巨噬细胞是机体固有免疫系统的重要组成部分，糖代谢重编程通过糖酵解介导M1型巨噬细胞极化。巨噬细胞的极化与免疫稳态和母胎免疫耐受密切相关，在复发性流产的发病机制中起着不可或缺的作用。M1型巨噬细胞引起的炎症反应会干扰滋养层细胞从而引发不良妊娠结局。该文对复发性流产中巨噬细胞糖代谢重编程相关研究进行综述，以期为复发性流产的治疗提供思路。

Abstract:

Macrophages are an important component of the body's innate immune system, and glucose metabolism reprogramming mediates M1 macrophage polarization through glycolysis. The polarization of macrophages is closely related to immune homeostasis and maternal fetal immune tolerance, and plays an indispensable role in the pathogenesis of recurrent abortion. The inflammatory response caused by M1 macrophages can interfere with trophoblast cells, leading to adverse pregnancy outcomes. This article summarizes the research on macrophage glucose metabolism reprogramming in recurrent abortion, in order to provide ideas for the treatment of recurrent abortion.