中性粒细胞自我牺牲在急性肺损伤中的作用

The role of neutrophils self-sacrifice in the acute lung injury

摘要:

细胞是构成生命体的基本单位，生物体由于衰老或受到损伤造成细胞死亡。细胞死亡根据其形态可分为凋亡、坏死性凋亡、铁死亡、焦亡、胞外诱捕网、自噬及铜死亡等类型。急性肺损伤是临床常见危重症，发生时常伴随着免疫细胞的激活和死亡。中性粒细胞作为急性肺损伤发展进程中最重要的效应细胞之一，在响应急性肺损伤病理生理过程中发挥着重要的作用。该文结合生物信息学方法深入了解中性粒细胞在急性肺损伤发展中的死亡方式及病理学意义，对阻止其进一步发展为急性呼吸窘迫综合征提供参考。

Abstract:

Cells are the fundamental units that constitute living organisms, and they can die due to aging or damage. Cell death can be classified into various types based on its morphology, including apoptosis, necroptosis, ferroptosis, pyroptosis, extracellular trappings, autophagy and cuproptosis. In clinical practice, acute lung injury (ALI) often occurs in critical cases and is frequently accompanied by the activation and death of immune cells. Neutrophils as one of the most important effector cells in the development process of ALI, play a significant role in responding to the pathophysiological process of ALI. This article employs bioinformatics methods to gain a deeper understanding of the mode of neutrophils death and its pathological significance in the development, providing references for preventing its further progression into acute respiratory distress syndrome (ARDS).