富血小板纤维蛋白填塞联合米诺环素治疗慢性根尖周炎对患者炎症反应的影响

Effect of platelet-rich fibrin packing combined with minocycline on inflammatory response in patients with chronic apical periodontitis

摘要:

目的 探究富血小板纤维蛋白（PRF）填塞联合米诺环素治疗慢性根尖周炎（CAP）对患者炎症反应的影响。方法 回顾性选取2020年6月—2023年6月在延安市中医医院进行诊治的CAP患者103例，根据治疗方法分成两组。对照组（52例）予以米诺环素软膏填充，观察组（51例）予以PRF填塞联合米诺环素软膏填充。比较两组疗效、视觉模拟评分法（VAS）评分、牙齿功能、炎症水平、生活质量及安全性评估。结果 观察组手术成功率高于对照组（P <0.05）。观察组手术前后VAS评分、神经肽Y、前列腺素E2、咀嚼效率、咬合能力、白三烯B4、白细胞介素-1β、细胞间黏附分子-1、Toll样受体4、5条目口腔健康影响程度评分的差值均高于对照组（P <0.05）。观察组与对照组安全性比较，差异无统计学意义（P >0.05）。结论 PRF填塞联合米诺环素用于CAP临床治疗，可有效减轻术后早期疼痛及炎症水平，提高手术成功率，从而促进患者牙齿功能及生活质量的改善，且安全性较高。

Abstract:

Objective To investigate the effect of platelet-rich fibrin (PRF) packing combined with minocycline on inflammatory response in patients with chronic apical periodontitis (CAP).Methods We retrospective selected 103 CAP patients diagnosed and treated in our hospital between June 2020 to June 2023 and divided them into two groups according to the treatment method. The control group (52 cases) received minocycline ointment filling, while the observation group (51 cases) PRF packing combined with minocycline ointment filling. The curative effect, Visual Analogue Scale (VAS) scores, dental function, inflammation levels, quality of life and the safety profile were compared between the two groups.Results The success rate of the operation in the observation group was higher than that in the control group (P < 0.05). The differences in the VAS scores, neuropeptide Y, prostaglandin E2, masticatory efficiency, occlusal force, leukotriene B4, interleukin-1β, intercellular adhesion molecule-1, Toll-like receptor 4 and OHIP-5 scores before and after the operation in the observation group were greater compared with the control group (P < 0.05). There was no difference in the safety profile between the two groups (P > 0.05).Conclusions PRF packing combined with minocycline in the clinical treatment of CAP can effectively alleviate early postoperative pain and inflammation, improve surgical success rates, and enhance dental function and quality of life, while maintaining a high level of safety.