多囊卵巢综合征子宫内膜局部相关分子变化的研究进展

Research progress on local molecular alterations in the endometrium associated with polycystic ovary syndrome

摘要:

多囊卵巢综合征（PCOS）是以雄激素过多、生育功能障碍和卵巢多囊样改变等为主要表现的临床综合征，是生育年龄妇女最普遍的内分泌疾病，是最常见的不孕因素。PCOS患者存在子宫内膜容受性失调，严重影响着PCOS患者的妊娠率，增加患者的流产率。该文基于蛋白组学、转录组学和DNA甲基化等就PCOS子宫内膜容受性相关因素进行综述，阐述了与PCOS子宫内膜容受异常有关的蛋白、mRNA、非编码RNA和DNA甲基化，为改善PCOS患者妊娠率的基础研究和临床诊治提供思路。

Abstract:

Polycystic ovary syndrome (PCOS) is a clinical syndrome characterized by hyperandrogenism, reproductive dysfunction, and polycystic ovary morphology. It is the most common endocrine disorder in women of reproductive age and a leading cause of infertility. Recent studies have found that PCOS patients have endometrial receptivity disorders, which severely affect the pregnancy rate and increase the miscarriage rate in PCOS patients. This review summarizes factors affecting the endometrial receptivity in PCOS from the perspectives of proteomics, transcriptomics, and DNA methylation. It discusses proteins, mRNAs, non-coding RNAs, and DNA methylation associated with abnormal endometrial receptivity in PCOS, providing insights for basic research and clinical management aimed at improving pregnancy rates in PCOS patients.