果酸联合润肌皮肤膏、表皮生长因子凝胶对轻中度痤疮患者皮肤屏障功能的影响及疗效

The effect of glycolic acid combined with Runji Skin Ointment and epidermal growth factor gel on the treatment and skin barrier function of patients with mild to moderate acne

摘要:

目的 探讨果酸联合润肌皮肤膏、表皮生长因子凝胶对轻中度痤疮患者的疗效及对皮肤屏障功能的影响。方法 选取2021年4月—2024年4月山东省第二人民医院皮肤科收治的82例轻中度痤疮患者为研究对象。按照随机数字表法分为对照组（润肌皮肤膏、表皮生长因子凝胶治疗）与试验组（在对照组基础上使用果酸治疗），每组41例。对比两组患者皮损、红斑情况、皮肤屏障功能、痤疮后色素沉着指数（PAHPI）及不良反应。结果 治疗前后试验组患者皮肤的颜色、痤疮数量、疼痛评分差值均高于对照组（P <0.05）。治疗后即刻及治疗后2个月试验组患者的实用临床医师红斑评估量表评分低于对照组（P <0.05）。治疗前后试验组患者的皮脂含量、角质层水分含量、经表皮水分流失量的差值及PAHPI评分的差值均高于对照组（P <0.05）。试验组与对照组的不良事件发生率比较，差异无统计学意义（P >0.05）。结论 果酸联合润肌皮肤膏及EGF凝胶治疗可以显著改善轻中度痤疮患者的临床症状，提高皮肤屏障功能，且安全性良好，适合临床推广使用。

Abstract:

Objective To investigate the efficacy of glycolic acid combined with Runji Skin Ointment and epidermal growth factor (EGF) gel in treating mild to moderate acne and their effects on skin barrier function.Methods Eighty-two patients with mild to moderate acne were randomized using a random number table into a control group (n = 41), receiving topical Runji Skin Ointment and EGF gel twice daily, and an experimental group (n = 41), receiving additional glycolic acid treatment. Outcomes included lesion severity, erythema, skin barrier parameters, post-acne hyperpigmentation index (PAHPI), and adverse events.Results The experimental group showed significantly lower scores in lesion color, count, and pain intensity compared to the control group (P < 0.05). At treatment completion and 2-month follow-up, erythema scores in the experimental group were lower (P < 0.05). Greater improvements in sebum content, stratum corneum hydration, trans-epidermal water loss reduction, and PAHPI decrease were observed in the experimental group (P < 0.05). Adverse events did not differ between groups (P > 0.05).Conclusion The combination therapy synergistically improves acne symptoms, enhances skin barrier function, and reduces hyperpigmentation, demonstrating efficacy and safety for clinical use.