依达拉奉右莰醇联合奥拉西坦治疗老年血管性痴呆的临床效果及对神经功能的影响

Therapeutic effects of edaravone dexborneol combined with oxiracetam in senile vascular dementia and its impact on neurological function

摘要:

目的 探讨依达拉奉右莰醇联合奥拉西坦治疗老年血管性痴呆（VaD）的临床效果及对神经功能的影响。方法 回顾性分析2021年5月—2024年9月邢台市中心医院收治的99例老年VaD患者，按不同治疗方法分为对照组和观察组，分别有48、51例。对照组采取奥拉西坦治疗，观察组另加用依达拉奉右莰醇治疗，比较两组疗效。结果 观察组有效率高于对照组（P <0.05）。观察组治疗前后简易精神状态检查量表、Blessed行为量表评分的差值均低于对照组（P <0.05）。观察组治疗前后同型半胱氨酸、中枢神经特异性蛋白β的差值均高于对照组（P <0.05），中脑源性神经营养因子的差值低于对照组（P <0.05）。观察组治疗前后全血黏度、血细胞比容、血浆黏度的差值均高于对照组（P <0.05）。观察组治疗前后血流速度、平均血流量的差值低于对照组（P <0.05），血管搏动指数的差值高于对照组（P <0.05）。两组患者治疗期间均未发生严重不良反应。结论 老年VaD患者采取依达拉奉右莰醇联合奥拉西坦治疗，可显著改善脑循环动力学和血液流变学指标，提升患者认知功能和行为能力，临床应用安全性尚可。

Abstract:

Objective To analyze the therapeutic effects of edaravone dexborneol combined with oxiracetam in senile vascular dementia (VaD) and its impact on neurological function.Methods The 99 elderly patients with VaD admitted to Xingtai Central Hospital from May 2021 to September 2024 were retrospectively analyzed. They were divided into the control and observation groups according to different treatment methods. The control group (n = 48) was treated with oxiracetam, and the observation group (n = 51) was additionally treated with edaravone dexborneol. The therapeutic outcome of the two groups was compared.Results The effective rate of the observation group was higher than that of the control group (P < 0.05). The differences of MMSE and BBS scores before and after treatment in the observation group were lower than those in the control group (P < 0.05). The differences of Hcy and S100β levels before and after treatment in the observation group were higher than those in the control group (P < 0.05), and the difference of the BDNF level before and after treatment in the observation group was lower than that in the control group (P < 0.05). The differences of whole blood viscosity, hematocrit and plasma viscosity before and after treatment in the observation group were higher than those in the control group (P <0.05). The differences of blood flow velocity and average blood flow before and after treatment in the observation group were lower than those in the control group (P <0.05), and the difference of vascular pulsatility index before and after treatment in the observation group was higher than that in the control group (P <0.05).Conclusion In elderly patients with VaD, edaravone dexborneol combined with oxiracetam significantly improves cerebral circulation dynamics and hemorheology indexes, enhances cognitive and behavioral functions, and demonstrates a favorable safety profile for clinical use.