胃癌治疗的新视角：铁死亡和血管生成拟态

A new perspective on gastric cancer treatment: ferroptosis and vasculogenic mimicry

摘要:

胃癌是世界范围内致死率高的恶性肿瘤之一，预后状况不容乐观。铁死亡作为一种依赖铁的细胞死亡形式，近年来在胃癌发生、发展中的作用成为了研究热点。此外，血管生成拟态（VM）作为一种不依赖于内皮细胞或传统血管生成的肿瘤血液供应途径，能显著影响胃癌的预后和治疗效果。因此，深入探索铁死亡和VM的关联，可能有助于发现新的胃癌诊断标志物和治疗靶点，提高胃癌的生存率。该文首次系统综述了铁死亡与VM在胃癌中的双向调控机制，并提出了靶向联合治疗的潜在策略。

Abstract:

Gastric cancer is one of the most lethal malignancies worldwide and is associated with a poor prognosis. Ferroptosis, a form of cell death dependent on iron, has become a research hotspot in recent years due to its role in the development and progression of gastric cancer. Additionally, vasculogenic mimicry (VM), a tumor-associated blood supply mechanism that functions independently of endothelial cells or traditional angiogenesis, has been proven to significantly impact the prognosis and treatment outcomes of gastric cancer. Therefore, exploring the relationship between ferroptosis and VM may help identify new diagnostic biomarkers and therapeutic targets for gastric cancer, thereby improving patient survival rates. This review is the first to systematically summarize the bidirectional regulatory mechanisms between ferroptosis and VM in gastric cancer, and to propose potential strategies for targeted combination therapy.