美沙拉嗪肠溶片联合茵陈蒿汤对湿热内蕴证慢性溃疡性结肠炎患者氧化应激及炎症反应的影响

Effects of mesalazine enteric-coated tablets combined with Yinchenhao Decoction on oxidative stress and inflammation in patients with chronic ulcerative colitis with dampness-heat syndrome

摘要:

目的 分析美沙拉嗪肠溶片联合茵陈蒿汤对湿热内蕴证慢性溃疡性结肠炎（CUC）患者氧化应激及炎症反应的影响。方法 回顾性分析2022年7月—2024年5月在宝鸡市中医医院就诊的87例湿热内蕴证CUC患者的病历资料，以随机数字表法分为观察组（45例）、对照组（42例）。对照组采用美沙拉嗪肠溶片治疗，观察组在对照组基础上采用茵陈蒿汤治疗。比较两组中医症候评分、炎症反应、肠道屏障功能、临床疗效、氧化应激反应及不良反应。结果 观察组治疗前后主症评分、次症评分和总评分的差值均大于对照组（P <0.05）。观察组治疗前后白细胞介素-4、红细胞沉降率、肿瘤坏死因子-β的差值均大于对照组（P <0.05）。观察组治疗前后内毒素、二胺氧化酶和D-乳酸的差值均大于对照组（P <0.05）。观察组总有效率高于对照组（P <0.05）。观察组治疗前后超氧化物歧化酶和丙二醛的差值均大于对照组（P <0.05）。两组总有效率比较，差异无统计学意义（P >0.05）。结论 湿热内蕴证CUC患者接受美沙拉嗪肠溶片联合茵陈蒿汤治疗效果显著，可改善肠道屏障功能，减轻炎症反应与氧化应激反应，且安全可靠。

Abstract:

Objective To analyze the effects of mesalazine enteric-coated tablets combined with Yinchenhao Decoction on oxidative stress and inflammation in patients with chronic ulcerative colitis (CUC) with dampness-heat syndrome.Methods The medical records of 87 patients with CUC with dampness-heat syndrome at Baoji Hospital of Traditional Chinese Medicine from July 2022 to May 2024 were retrospectively analyzed, and they were divided into the observation group (45 cases) and the control group (42 cases) by the random number table method. The control group was treated with mesalazine enteric-coated tablets, while the observation group received additional treatment with Yinchenhao Decoction based on the same regimen as the control group. Traditional Chinese medicine (TCM) syndrome scores, inflammatory response, intestinal barrier function, clinical efficacy, oxidative stress response and adverse reactions were compared between the two groups.Results The differences in the main syndrome scores, secondary syndrome scores and total TCM syndrome scores before and after treatment in the observation group were all greater than those in the control group (P < 0.05). The differences in interleukin-4 levels, erythrocyte sedimentation rate, and tumor necrosis factor-β levels before and after treatment in the observation group were all greater than those in the control group (P < 0.05). The differences in levels of endotoxin, diamine oxidase and D-lactic acid before and after treatment in the observation group were all greater than those in the control group (P < 0.05). The overall effective rate of the observation group was higher than that of the control group (P < 0.05). The differences in levels of superoxide dismutase and malondialdehyde before and after treatment in the observation group were greater than those in the control group (P < 0.05). There was no statistically significant difference in the overall effective rate between the two groups (P > 0.05).Conclusion The combination of mesalazine enteric-coated tablets and Yinchenhao Decoction demonstrates significant therapeutic efficacy in patients with CUC with dampness-heat syndrome. It effectively improves intestinal barrier function, reduces inflammatory and oxidative stress responses, and is safe and well-tolerated.