胸部高分辨率计算机断层扫描预测结缔组织病相关间质性肺疾病转归的研究进展

Research progress of chest high-resolution computed tomography in predicting the outcome of interstitial lung disease associated with connective tissue disease

摘要:

结缔组织病（CTD）是一组免疫介导的累及多个系统或器官的自身免疫性疾病。间质性肺疾病（ILD）是CTD最常见的并发症之一，ILD进展可导致不可逆转的肺功能丧失，使患者生存期缩短，因此早期识别CTD-ILD进展至关重要。胸部高分辨率计算机断层扫描（HRCT）是CTD-ILD重要的诊断和监测工具，其评估ILD的方法包括视觉评估、定量CT等。近年来定量CT的开发和应用受到重视。该文对胸部HRCT影像学变化预测CTD-ILD转归的相关文献进行总结，从胸部HRCT影像学特征及分型、半定量、定量CT等方面进行综述。

Abstract:

Connective tissue diseases (CTD) constitute a group of immune-mediated autoimmune disorders that affect multiple systems or organs. Interstitial lung disease (ILD) is one of the most prevalent complications of CTD. The advancement of ILD can result in irreversible lung function loss and a shortened lifespan for patients. Thus, early identification of the progression of CTD-ILD is of paramount importance. High-resolution computed tomography (HRCT) of the chest serves as a significant diagnostic and monitoring tool for CTD-ILD. The approaches for evaluating ILD on HRCT encompass visual assessment, quantitative CT (QCT), etc. In recent years, the development and application of QCT methods have garnered significant attention. This article summarizes the relevant literature on the prediction of the prognosis of CTD-ILD through changes in thoracic HRCT imaging and conducts a review from aspects such as the imaging features and classification of thoracic HRCT, semi-quantitative methods, and QCT.