Notch信号通路在血管新生方面的研究进展

Research progress on the role of Notch signaling pathway in angiogenesis

摘要:

神经源性位点缺口同源蛋白（Notch）信号通路参与调节细胞增殖、分化和凋亡过程，Notch信号通路的失调会导致多种疾病的发生。血管新生是一个复杂的生物学过程，Notch信号通路通过DLL4/Notch信号轴参与血管生成过程，影响内皮细胞的增殖。Notch信号通路调控血管新生的过程参与多种疾病的发生、发展，如癌症、心脑血管疾病和糖尿病。因此通过研究Notch信号通路调控血管新生的过程，可以更好地阐明该信号通路在疾病发生机制中的作用，还可能对相关疾病的诊断和治疗提供新思路。

Abstract:

The Notch signaling pathway plays a critical role in regulating cell proliferation, differentiation, and apoptosis, and its dysregulation has been implicated in the pathogenesis of multiple diseases. Angiogenesis is a complex biological process, and the Notch pathway, particularly through the DLL4/Notch signaling axis, is involved in the regulation of angiogenesis, affecting endothelial cell proliferation. Aberrant Notch signaling-mediated regulation of angiogenesis contributes to the onset and progression of various diseases, including cancer, cardiovascular and cerebrovascular disorders, and diabetes mellitus. Investigating the role of Notch signaling in angiogenesis is therefore essential for elucidating its contribution to disease mechanisms and may offer novel insights for the diagnosis and treatment of related conditions.