Abstract:Objective To investigate the clinical efficacy of fire needle therapy combined with meridian-based cupping on pain relief and functional improvement in patients with cervical and shoulder myofascial pain syndrome.Methods From January 2023 to December 2024, 82 patients with cervical and shoulder myofascial pain syndrome admitted to our hospital were selected as the study subjects. Using a random number table, the patients were divided into a control group (n = 41, receiving conventional treatment) and an observation group (n = 41, receiving fire needle therapy combined with meridian-based cupping in addition to the conventional treatment). Pain-related indicators, cervical function indicators, inflammatory markers, quality of life [using the SF-36 scale], and the incidence of adverse reactions were compared between the two groups.Results In the observation group, post-treatment Visual Analog Scale (VAS) scores for neck and shoulder pain were significantly lower than those in the control group (P < 0.05), with significantly greater pre-post treatment differences in VAS scores (P < 0.05). Cervical Range of Motion (CROM) scores and cervical mobility were significantly higher in the observation group post-treatment compared with the control group (P < 0.05), whereas Neck Disability Index (NDI) scores were significantly lower (P < 0.05). The pre-post treatment differences in CROM, NDI, and cervical mobility were significantly greater in the observation group (P < 0.05). Serum levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and procalcitonin (PCT) were significantly lower in the observation group post-treatment (P < 0.05), with significantly greater reductions (pre-post differences) observed compared with the control group (P < 0.05). Regarding quality of life assessments, the observation group demonstrated significantly higher post-treatment scores in physical functioning, role-physical, bodily pain, and general health compared with the control group (P < 0.05), with significantly greater improvements (pre-post differences) in these domains (P < 0.05). No statistically significant difference was observed in the overall incidence of adverse reactions between the two groups (P > 0.05).Conclusion Fire needle therapy combined with meridian-based cupping significantly alleviates pain, improves functional status, reduces muscle tension, and enhances the quality of life in patients with cervical and shoulder myofascial pain syndrome. The treatment is safe and readily applicable in clinical practice.