喹硫平联合丙戊酸镁治疗对双相情感障碍主客观睡眠及白细胞介素-6受体mRNA表达的影响

Effects of quetiapine combined with magnesium valproate on subjective and objective sleep and IL-6 receptor mRNA expression in patients with bipolar disorder

摘要:

目的 探讨喹硫平联合丙戊酸镁治疗对双相情感障碍患者主观和客观睡眠质量，以及白细胞介素-6（IL-6）受体mRNA表达的影响。方法 选取2022年3月—2024年2月太原市精神病医院收治的106例双相情感障碍患者，随机分为对照组和观察组，各53例。对照组接受丙戊酸镁治疗，观察组接受喹硫平联合丙戊酸镁治疗。比较两组的治疗效果及治疗前后睡眠质量和IL-6受体mRNA相对表达量。结果 观察组治疗总有效率为90.6%，高于对照组的69.8%（P <0.05）。观察组治疗前后匹兹堡睡眠质量指数评分的差值大于对照组（P <0.05）。观察组治疗前后总睡眠时间、睡眠效率、睡眠潜伏期、REM潜伏期和觉醒次数的差值均大于对照组（P <0.05）。观察组治疗前后IL-6受体mRNA相对表达量的差值大于对照组（P <0.05）。结论 喹硫平联合丙戊酸镁治疗能够显著提升双相情感障碍患者的主观和客观睡眠质量，并降低IL-6受体mRNA的表达，疗效优于单一丙戊酸镁治疗。

Abstract:

Objective To investigate the effects of combined treatment with quetiapine and magnesium valproate on both subjective and objective sleep quality and interleukin-6 (IL-6) receptor mRNA expression in patients with bipolar disorder.Methods A total of 106 patients with bipolar disorder treated at Taiyuan Psychiatric Hospital from March 2022 to February 2024 were randomly divided into two groups, each with 53 cases. The control group received magnesium valproate treatment, while the observation group received a combination of quetiapine and magnesium valproate. The treatment outcomes, sleep quality, and IL-6 receptor mRNA expression levels were compared between the groups before and after treatment.Results The overall effective rate of treatment in the observation group was 90.6%, significantly higher than that in the control group (69.8%; P < 0.05). The observation group demonstrated a significantly greater reduction in Pittsburgh Sleep Quality Index (PSQI) scores from baseline to post-treatment compared to the control group (P < 0.05). Furthermore, the changes in total sleep time, sleep efficiency, sleep latency, REM latency, and number of awakenings before and after treatment were all more pronounced in the observation group than in the control group (P < 0.05). Additionally, the changes in relative IL-6 receptor mRNA expression from pre- to post-treatment were greater in the observation group than in the control group (P < 0.05).Conclusion The combination of quetiapine and magnesium valproate significantly improves both subjective and objective sleep quality and reduces IL-6 receptor mRNA expression in patients with bipolar disorder, showing superior efficacy compared to treatment with magnesium valproate alone.