人类职能模式康复训练结合文娱疗法对稳定期精神分裂症患者的康复疗效

The therapeutic effect of combining human functional rehabilitation training with recreational therapy on stable schizophrenia patients

摘要:

目的 评估人类职能模式康复训练结合文娱疗法对稳定期精神分裂症患者康复效果的影响。方法 选取2022年6月—2024年5月丽水市第二人民医院120例稳定期精神分裂症患者作为研究对象，按照随机数字表法分为观察组与对照组，每组60例。观察组采用人类职能模式康复训练结合文娱疗法进行康复治疗，对照组实行常规康复治疗。观察两组患者治疗前后住院精神病人康复疗效评定量表（IPROS）和可重复神经心理状态测验问卷（RBANS）评分、阳性与阴性症状量表（PANSS）、阴性症状评定量表（SANS）、认知功能评分、一般疏离感量表（GAS）及神经递质［谷氨酸（Glu）、γ-氨基丁酸（GABA）、5-羟色胺（5-HT）、去甲肾上腺素（NE）］等指标的变化。结果 观察组治疗前后IPROS和RBANS评分的差值均大于对照组（P <0.05）。观察组治疗前后PANSS各项评分的差值均大于对照组（P <0.05）。观察组治疗前后SANS各项评分的差值均大于对照组（P <0.05）。观察组治疗前后认知功能各项评分的差值均大于对照组（P <0.05）。观察组治疗前后GAS各项评分的差值均大于对照组（P <0.05）。观察组治疗前后Glu、GABA、5-HT及NE水平的差值均大于对照组（P <0.05）。结论 人类职能模式康复训练结合文娱疗法对稳定期精神分裂症患者的康复具有显著效果，可作为一种有效的康复治疗策略推广应用。

Abstract:

Objective This study aimed to evaluate the effectiveness of integrating human functional rehabilitation training with recreational therapy on the recovery of stable schizophrenia patients.Method Between June 2022 and May 2024, 120 stable schizophrenia patients at Lishui Second People's Hospital were randomly assigned to two groups using a number table method. The observation group (60 cases) received rehabilitation treatment combining human functional mode rehabilitation training with recreational therapy, while the control group (60 cases) underwent standard rehabilitation treatment. Changes in IPROS score, RBANS score, positive symptoms, negative symptoms, general pathological score, SANS score, cognitive function, GAS score, and neurotransmitter levels [glutamate (Glu), gamma-aminobutyric acid (GABA), serotonin (5-HT), norepinephrine (NE) ] were assessed before and after intervention.Results The observation group demonstrated significantly greater improvements in IPROS and RBANS scores compared to the control group (P < 0.05). Greater reductions in positive symptoms, negative symptoms, and general psychopathology scores were observed in the observation group (P < 0.05). Significant improvements were also noted in total scores, affective flattening, speech disorders, avolition, social anhedonia, and attention deficits (P < 0.05). The observation group showed superior performance in cognitive tasks, including completed categories, total responses, perseverative errors, total errors, and correct responses (P < 0.05). Enhanced GAS scores and significant changes in neurotransmitter levels (Glu, GABA, 5-HT, NE) were observed in the observation group (P < 0.05).Conclusion Integrating human functional rehabilitation training with recreational therapy significantly enhances the rehabilitation of stable schizophrenia patients, suggesting it as a promising strategy for clinical practice.