桔贝合剂联合亚胺培南西司他丁钠治疗社区获得性肺炎伴呼吸衰竭的效果

Effectiveness of Jubei Mixture in combination with imipenem and cilastatin sodium in the treatment of community-acquired pneumonia with respiratory failure

摘要:

目的 探讨桔贝合剂联合亚胺培南西司他丁钠治疗社区获得性肺炎（CAP）伴呼吸衰竭（RF）的效果及对炎症因子和血气指标的影响。方法 选取2021年3月—2024年3月中国人民解放军联勤保障部队第九〇四医院常州医疗区接诊的CAP伴RF患者86例，采用奇偶数字法随机分为观察组、对照组，各43例。对照组给予亚胺培南西司他丁钠治疗，观察组在对照组基础上联合桔贝合剂治疗。治疗7 d后，比较两组的血气指标、肺功能、炎症因子、心肾功能、疗效及不良反应。结果 观察组治疗前后血氧分压、血二氧化碳分压及氧合指数、最大呼气流量、用力肺活量、第1秒用力呼气量、肿瘤坏死因子-α、可溶性髓系细胞触发受体-1的差值均大于对照组（P <0.05）。观察组治疗有效率高于对照组（P <0.05）。两组不良反应总发生率比较，差异无统计学意义（P >0.05）。结论 桔贝合剂联合亚胺培南西司他丁钠治疗CAP伴RF，有助于促进患者肺功能的恢复，安全性良好。

Abstract:

Objective To investigate the effectiveness of Jubei Mixture combined with imipenem and cilastatin sodium in the treatment of community-acquired pneumonia (CAP) with respiratory failure (RF) and its effect on inflammatory factors and blood gas indexes.Methods Eighty-six patients with CAP with RF admitted to our hospital from March 2021 to March 2024 were selected and randomly divided into 43 cases in the observation group and 43 cases in the control group using the odd-even number method. The control group was treated with imipenem and cilastatin sodium, and the observation group was additionally given Jubei Mixture. After 7 days of treatment, the two groups were compared in terms of blood gas indexes, lung function, inflammatory factors, cardiac and renal function, therapeutic efficacy and adverse reactions.Results The differences of partial pressure of oxygen, partial pressure of carbon dioxide, oxygenation index, peak expiratory flow, forced vital capacity, forced expiratory volume in 1 second, and levels of tumor necrosis factor-α and soluble triggering receptor expressed on myeloid cells-1 before and after treatment in the observation group were all greater than those in the control group (P < 0.05). The effective rate in the observation group was higher than that in the control group (P < 0.05). There was no significant difference in the incidence of total adverse reactions between the observation group and the control group (P > 0.05).Conclusion Jubei Mixture combined with imipenem and cilastatin sodium for the treatment of CAP with RF promotes the recovery of pulmonary function and demonstrates a favorable safety profile.