勃起功能障碍与动脉粥样硬化指标的关系研究进展

Advances in the relationship between erectile dysfunction and atherogenic indexes

摘要:

勃起功能障碍是男性健康领域的重要临床问题，其病理生理机制与血管内皮功能密切相关。近年研究表明，勃起功能障碍不仅是男性性功能障碍的表现，更是全身血管系统病变的早期生物学标志。动脉粥样硬化作为心血管疾病的核心病理基础，其相关评估指标与勃起功能障碍的发生、发展存在显著关联。该研究重点关注4项具有临床价值的动脉粥样硬化指标：血浆致动脉硬化指数、动脉粥样硬化指数、Castelli风险指数-1及Castelli风险指数-2。上述指标通过评估脂质代谢异常和血管内皮功能障碍，能够客观反映动脉粥样硬化的进展程度，有助于建立心血管疾病的早期预警体系，更能为勃起功能障碍的预防和干预提供新的临床思路。

Abstract:

Erectile dysfunction (ED) is a significant clinical issue in the field of male health, with its pathophysiological mechanisms closely linked to vascular endothelial function. Recent studies have shown that ED is not only a manifestation of male sexual dysfunction but also an early biomarker of systemic vascular disease. Atherosclerosis, as the core pathological basis of cardiovascular disease, is significantly associated between its related evaluation indices and the development of ED. This study focuses on four clinically relevant atherosclerotic indices: the atherogenic index of plasma, atherogenic coefficient, Castelli's risk index-1, and Castelli's risk index-2. These composite indices objectively reflect the progression of atherosclerosis by assessing lipid metabolism disorders and vascular endothelial dysfunction, thereby contributing to the establishment of an early warning system for cardiovascular diseases. Furthermore, they provide novel clinical insights for the prevention and intervention of ED.