线粒体、内质网膜上钙离子蛋白对椎间盘退行性病变的影响

The role of calcium-related proteins on the mitochondrial and endoplasmic reticulum membranes in intervertebral disc degeneration

摘要:

椎间盘退变是导致腰痛的主要原因，对人类社会和经济造成了严重的负担。查阅线粒体、内质网、椎间盘退变等相关文献发现，钙离子在三者的联系中发挥着重要作用。钙离子稳态失衡是椎间盘退变的关键因素之一，通过影响线粒体、内质网和线粒体-内质网结构偶联的功能，调节细胞增殖、分化、凋亡和能量代谢在内的多种过程。该文聚焦于线粒体、内质网膜上钙离子蛋白对椎间盘退变的影响，旨在为后续椎间盘退变的机制研究、构建机制网络，以及钙离子蛋白靶向药物的研发提供思路。

Abstract:

Intervertebral disc degeneration (IDD) is the primary cause of low back pain, imposing a significant burden on both human society and the economy. A review of relevant literature on mitochondria, endoplasmic reticulum, and IDD reveals that calcium ions play a crucial role in mediating the interactions among these three components. The imbalance of calcium ion homeostasis is one of the key factors contributing to IDD. This imbalance disrupts the functions of mitochondria, the endoplasmic reticulum, and their structural coupling, thereby influencing various cellular processes such as proliferation, differentiation, apoptosis, and energy metabolism. This review focuses on the role of calcium-related proteins located on mitochondrial and endoplasmic reticulum membranes in IDD, aiming to provide insights for future research on the underlying mechanisms, the construction of regulatory networks, and the development of calcium-related protein-targeted therapies.