横纹肌肉瘤转移机制的研究进展及干预治疗策略

Advances in metastatic mechanisms and therapeutic strategies for rhabdomyosarcoma

摘要:

横纹肌肉瘤（RMS）是儿童和青少年中最常见的软组织恶性肿瘤。尽管多学科治疗下取得了一定进展，但转移性RMS患者的预后仍较差，生存率极低。该文综述了RMS的转移机制，重点探讨了相关信号通路、分子特征及肿瘤微环境的影响，并关注了RMS的靶向干预和免疫治疗，以期为临床治疗提供参考思路。

Abstract:

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children and adolescents. Despite advancements in multidisciplinary therapeutic strategies, the prognosis for patients with metastatic RMS remains poor, with survival rates still dismal. This review provides a comprehensive summary of the metastatic mechanisms of RMS, with a specific focus on the relevant signaling pathways, molecular characteristics, and the influence of the tumor microenvironment. It also highlights targeted interventions and immunotherapy in RMS, aiming to offer novel insights for clinical therapeutic strategies.