肥大细胞在肿瘤微环境中作用的研究进展

Progress on the role of mast cells in the tumor microenvironment

摘要:

肥大细胞在肿瘤微环境中扮演着复杂且多面的角色，既可促进也可抑制肿瘤进展，甚至发挥双向调节作用。一方面，肥大细胞通过释放多种血管生成因子、细胞外基质重塑酶以及免疫抑制性细胞因子，促进肿瘤血管生成、组织重构和免疫逃逸，从而支持肿瘤生长和侵袭。另一方面，其也能够招募并激活抗肿瘤免疫细胞——如T细胞和自然杀伤细胞——进而增强免疫监视和肿瘤清除能力。因此，肥大细胞是肿瘤免疫治疗的潜在靶点，治疗策略包括靶向其信号通路、稳定脱颗粒、调节介质释放等，为肿瘤治疗提供了新的视角和方法。

Abstract:

Mast cells play a multifaceted role in the tumor microenvironment, exhibiting promotive, inhibitory, or bidirectional regulatory effects on tumor progression. They promote tumor angiogenesis, tissue remodeling, and immune escape through the release of angiogenic factors, extracellular matrix remodeling enzymes, and immunosuppressive mediators. Conversely, mast cells can also recruit and activate immune cells, such as T cells and NK cells, to mediate anti-tumor responses. Therefore, mast cells represent potential targets for tumor immunotherapy. Current therapeutic strategies include targeting mast cell signaling pathways, stabilizing their degranulation, and regulating mediator release, thereby providing novel insights and approaches for tumor treatment.