巨噬细胞在慢性萎缩性胃炎中的研究进展

Research progress on macrophages in chronic atrophic gastritis

摘要:

慢性萎缩性胃炎（CAG）被世界卫生组织定义为胃癌前病变，癌变率可达7%，但其临床表现与普通胃炎相似，缺乏特异性，目前的治疗手段无法根本性逆转其疾病进程。巨噬细胞作为组织修复和重塑的关键细胞，能够通过极化表型转换调节CAG炎症反应和组织修复。该文综述了巨噬细胞在CAG发病机制和中西医干预中的研究进展，有助于揭示疾病的发展机制，为开发安全有效的治疗方法提供新思路，有望为CAG的诊治带来新的突破。

Abstract:

Chronic atrophic gastritis (CAG) is defined as a precancerous lesion of gastric cancer by the World Health Organization (WHO), with a malignant transformation rate of up to 7%. However, its clinical manifestations are similar to those of common gastritis and lack specificity, and current therapeutic strategies are unable to fundamentally reverse disease progression. As key cells involved in tissue repair and remodeling, macrophages can regulate the inflammatory response and tissue repair in CAG through polarized phenotypic switching. This review summarizes the research progress on the role of macrophages in the pathogenesis of CAG, as well as in both traditional Chinese and Western medical interventions, aiming to reveal the disease mechanism, to provide new insights for developing safe and effective therapies, and to bring new breakthroughs in the diagnosis and treatment of CAG.