达芬奇机器人辅助下结直肠癌根治术对患者围手术期指标、胃肠功能及氧化应激的影响

Effects of Da Vinci robot-assisted radical resection for colorectal cancer on perioperative parameters, gastrointestinal function and oxidative stress

摘要:

目的 探讨达芬奇机器人辅助下结直肠癌根治术对患者围手术期指标、胃肠功能及氧化应激的影响。方法 选取2021年1月—2024年12月上海中医药大学附属曙光医院收治的108例结直肠癌患者，以随机数字表法分为研究组与对照组，各54例。对照组接受腹腔镜结直肠癌根治术，研究组接受达芬奇机器人辅助下结直肠癌根治术。比较两组围手术期指标、胃肠功能、氧化应激水平、炎症反应、能量代谢指标及并发症。结果 研究组术后住院时间、术中出血量、术后首次排气时间、术后首次排便时间均少于对照组（P <0.05），手术时长、淋巴结清扫数目均多于对照组（P <0.05）。对照组术前与术后3 d的胃动素、胃泌素、超氧化物歧化酶、丙二醛、肿瘤坏死因子α、超敏C反应蛋白、视黄醇结合蛋白、转铁蛋白的差值均大于研究组（P <0.05）。两组并发症总发生率比较，差异无统计学意义（P >0.05）。结论 达芬奇机器人辅助下结直肠癌根治术可促进患者康复，改善患者胃肠功能，减轻氧化应激、炎症反应，抑制能量代谢波动，且安全性良好。

Abstract:

Objective To investigate the effects of Da Vinci robot-assisted radical resection for colorectal cancer on perioperative parameters, gastrointestinal function, and oxidative stress.Methods The 108 patients with colorectal cancer admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between January 2021 and December 2024 were enrolled, and they were randomly assigned to either the study group or the control group (54 patients each) using a random number table. The control group underwent laparoscopic radical resection for colorectal cancer, while the study group underwent Da Vinci robot-assisted radical resection for colorectal cancer. Perioperative parameters, gastrointestinal function, oxidative stress levels, inflammatory response, energy metabolism indicators, and complications were compared between groups.Results The study group had shorter postoperative length of hospital stay, less intraoperative blood loss, shorter time to first postoperative flatus, and shorter time to first postoperative defecation compared to the control group (P < 0.05), while the operative duration was longer and the number of lymph nodes dissected was greater in the study group than those in the control group (P < 0.05). The preoperative to postoperative day 3 changes in levels of motilin, gastrin, superoxide dismutase, malondialdehyde, tumor necrosis factor-α, high-sensitivity C-reactive protein, retinol-binding protein, and transferrin were greater in the control group than in the study group (P < 0.05). There was no statistically significant difference in the overall incidence of complications between the two groups (P > 0.05).Conclusion Da Vinci robot-assisted radical resection for colorectal cancer promotes patient recovery, improves gastrointestinal function, reduces oxidative stress and inflammatory responses, suppresses fluctuations in energy metabolism, and demonstrates favorable safety.