浆细胞样树突状细胞在多发性硬化中的作用研究进展

Research progress on the role of plasmacytoid dendritic cell in multiple sclerosis

摘要:

多发性硬化是一种以中枢神经系统脱髓鞘和轴突损伤为特征的自身免疫性疾病。浆细胞样树突状细胞因其在抗病毒免疫和免疫调节中的独特地位，逐渐成为多发性硬化研究的焦点。该文系统综述了浆细胞样树突状细胞的生物学特征及免疫功能，重点分析其在多发性硬化中向中枢募集的特征、功能亚型的变化及成熟功能的缺陷。同时，总结了当前多种临床多发性硬化治疗药物对浆细胞样树突状细胞功能的影响。深入理解浆细胞样树突状细胞的作用机制，为揭示多发性硬化发病机制和开发新型靶向治疗策略提供新的思路。

Abstract:

Multiple sclerosis is an autoimmune disease characterized by demyelination and axonal damage in the central nervous system. Plasmacytoid dendritic cell (pDC), due to its unique roles in antiviral immunity and immune regulation, has become the focus of multiple sclerosis research. This article systematically reviews the biological characteristics and immunological functions of the plasmacytoid dendritic cell (pDC), focusing on its recruitment to the central nervous system in multiple sclerosis, changes in functional subtypes, and maturational defects. At the same time, it summarizes the effects of various current clinical multiple sclerosis treatment drugs on pDC functions. Through a deeper understanding of the mechanism of action of pDC, new ideas are provided for revealing the pathogenesis of multiple sclerosis and developing novel targeted therapeutic strategies.