多酚用于肾脏疾病治疗的研究进展

Research progress of polyphenols in the treatment of kidney diseases

摘要:

近年来，肾脏疾病的全球发病率持续攀升，已成为一个备受关注的公共卫生问题。目前临床主要通过维持血流动力学稳定、酸碱和电解质平衡、控制血压血糖等对症支持治疗，以及血液透析、腹膜透析、肾移植等肾脏替代治疗对其进行干预，但至今仍缺乏特效药物。多酚作为一类源自植物中的天然活性化合物，具有优异的抗炎、抗氧化、代谢调节等多种生物活性，在肾脏疾病防治中表现出显著潜力。该文系统综述了多酚在多种肾脏疾病治疗中的最新研究进展，以期为相关药物的开发提供理论依据与研究思路。

Abstract:

In recent years, the global incidence of kidney diseases has continued to rise and has become a public health issue of concern. At present, these diseases are mainly managed through symptomatic and supportive treatments such as maintaining hemodynamic stability, acid-base and electrolyte balance, controlling blood pressure and blood glucose, as well as renal replacement therapies such as hemodialysis, peritoneal dialysis, and renal transplantation; however, specific therapeutic drugs are still lacking. As a class of naturally occurring plant-derived active compounds, polyphenols have excellent anti-inflammatory, antioxidant, metabolic regulation and other biological activities, showing significant potential in the prevention and treatment of kidney diseases. This paper systematically reviews the latest research progress of polyphenols in the treatment of various kidney diseases, to provide a theoretical basis and research ideas for the development of related drugs.