超声监测结合丁苯酞氯化钠对脑梗死介入治疗后再闭塞风险及神经功能恢复的影响研究

Effects of ultrasound monitoring combined with butylphthalide sodium chloride on the risk of reocclusion and neurological recovery after interventional therapy for cerebral infarction

摘要:

目的 探讨超声监测结合丁苯酞氯化钠对脑梗死介入治疗后再闭塞风险及神经功能恢复的影响。方法 选取2023年3月—2025年3月在邢台市中心医院接受脑梗死介入治疗的92例患者作为研究对象。按照随机数字表法分为对照组与观察组，各46例。对照组采用丁苯酞氯化钠治疗；观察组在对照组基础上联合超声检测。比较两组溶栓后血管再闭塞发生率、神经功能指标、血流动力学参数、神经损伤与修复标志物。结果 观察组血管再闭塞发生率低于对照组（P <0.05）。观察组治疗前后美国国立卫生研究院卒中量表、改良Rankin量表的评分差值均大于对照组（P <0.05）。观察组术前与术后24 h的脑血流量、脑血容量、平均通过时间差值均高于对照组（P <0.05）。观察组治疗前后血清胶质纤维酸性蛋白、钙结合蛋白B、神经元特异性烯醇化酶水平差值均大于对照组（P <0.05）。结论 超声监测结合丁苯酞氯化钠可有效降低脑梗死介入治疗后的再闭塞风险，促进神经功能恢复，改善脑血流灌注，有利于临床推广应用。

Abstract:

Objective To investigate the effects of ultrasound monitoring combined with butylphthalide sodium chloride on the risk of reocclusion and neurological recovery after interventional therapy for cerebral infarction.Methods A total of 92 patients who underwent interventional therapy for cerebral infarction in Xingtai Central Hospital from March 2023 to March 2025 were selected as the research subjects. They were divided into the control group and the observation group according to the random number table method, with 46 cases in each group. The control group was treated with butylphthalide sodium chloride; the observation group was treated with butylphthalide sodium chloride combined with ultrasound monitoring on the basis of the control group. The incidence of vascular reocclusion after thrombolysis, neurological function indices, hemodynamic parameters, and biomarkers of neuronal injury and repair were compared between the two groups.Results The incidence of vascular reocclusion in the observation group was significantly lower than that in the control group (P < 0.05). The differences in the scores of National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) before and after treatment in the observation group were greater than those in the control group (P < 0.05). The differences in cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) between pre-operation and 24 h post-operation in the observation group were higher than those in the control group (P < 0.05). The differences in serum levels of glial fibrillary acidic protein (GFAP), calcium-binding protein B (S-100B), and neuron-specific enolase (NSE) before and after treatment in the observation group were greater than those in the control group (P < 0.05).Conclusion Ultrasound monitoring combined with butylphthalide sodium chloride can effectively reduce the risk of reocclusion after interventional therapy for cerebral infarction, promote neurological recovery, improve cerebral blood perfusion, and is conducive to clinical promotion and application.