复方黄柏液坐浴对混合痔患者术后创面愈合及血清VEGF、bFGF的影响

Effects of Compound Huangbai Liquid for sitz bath on wound healing and serum levels of VEGF and bFGF after mixed hemorrhoid surgery

摘要:

目的 探讨复方黄柏液坐浴用于混合痔术后对创面愈合及血清血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）的影响。方法 回顾性分析2023年1月—2024年12月于合肥市第一人民医院行手术治疗的102例混合痔患者的临床资料。按照术后治疗方式分为复方黄柏组（55例）和康复新液组（47例）。比较两组术后创面愈合疗效、愈合时间、愈合率，比较两组创面水肿、渗液、肉芽生长评分和中医症候积分（大便不畅、便时鲜血、肛门肿痛）、血清学指标（VEGF、bFGF）、安全性。结果 复方黄柏组总有效率高于康复新液组（P <0.05）；复方黄柏组创面愈合时间更短、愈合率更高（P <0.05）；复方黄柏组治疗前后创面水肿、渗液和肉芽生长评分的差值均大于康复新液组（P <0.05）；复方黄柏组治疗前后大便不畅、便时鲜血、肛门肿痛症候积分的差值均大于康复新液组（P <0.05）；复方黄柏组治疗前后血清VEGF、bFG水平的差值均大于康复新液组（P <0.05）；两组患者均未出现明显不良反应。结论 复方黄柏液坐浴可促进混合痔术后创面愈合，还能提高血清VEGF、bFGF水平，安全性好。

Abstract:

Objective To investigate the effects of Compound Huangbai Liquid for sitz bath on wound healing and serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) following mixed hemorrhoid surgery.Methods A retrospective analysis was conducted on 102 patients with mixed hemorrhoids who underwent surgical treatment at Hefei First People’s Hospital from January 2023 to December 2024. According to postoperative treatment, the patients were divided into a Compound Huangbai Liquid group (n = 55) and a Kangfuxin Solution group (n = 47). Wound healing efficacy, healing time, and healing rate were compared between the two groups. Additionally, wound edema, exudation, and granulation tissue scores, as well as traditional Chinese medicine (TCM) symptom scores (difficulty in defecation, fresh blood during defecation, and anal pain/swelling), serum levels of VEGF and bFGF, and safety were evaluated.Results The overall effective rate in the Compound Huangbai Liquid group was higher than that in the Kangfuxin Solution group (P < 0.05). The Compound Huangbai Liquid group had a shorter wound healing time and a higher healing rate (P < 0.05). The changes in wound edema, exudation, and granulation tissue scores before and after treatment were greater in the Compound Huangbai Liquid group than in the Kangfuxin Solution group (P < 0.05). Similarly, the changes in TCM symptom scores (difficulty in defecation, fresh blood during defecation, and anal pain/swelling) and serum VEGF and bFGF levels were greater in the Compound Huangbai Liquid group than in the Kangfuxin Solution group (P < 0.05). No obvious adverse reactions were observed in either group.Conclusion Compound Huangbai Liquid for sitz bath promotes wound healing after mixed hemorrhoid surgery, increases serum VEGF and bFGF levels, and has a good safety profile.