双歧杆菌乳杆菌三联活菌片联合消旋卡多曲对儿童轮状病毒性腹泻的疗效分析

Efficacy of Bifidobacterium Lactobacillus triple live tablets combined with racecadotril in the treatment of rotavirus diarrhea in children

摘要:

目的 探究双歧杆菌乳杆菌三联活菌片联合消旋卡多曲对儿童轮状病毒性腹泻的疗效。方法 选取2022年6月—2025年6月成都市公共卫生临床医疗中心就诊的120例轮状病毒性腹泻患儿作为研究对象，采用简单随机化信封抽签法，将患儿分为常规组和联合组，各60例。常规组给予常规治疗，联合组在常规组的基础上给予双歧杆菌乳杆菌三联活菌片联合消旋卡多曲治疗，比较两组治疗后的临床疗效、临床症状改善情况、免疫指标水平［免疫球蛋白A（IgA）、IgG、IgM］、肠道菌群含量及胃肠激素水平［胃泌素（GAS）、胃动素（MOT）、血管活性肠肽（VIP）］。结果 联合组总有效率高于常规组（P <0.05）。联合组止泻时间、止吐时间、退热时间和大便性状恢复正常时间均短于常规组（P <0.05）。联合组治疗后IgA、IgG、IgM高于常规组（P <0.05）。联合组治疗前后IgA、IgG、IgM的差值均大于常规组（P <0.05）。联合组治疗后肠杆菌含量低于常规组（P <0.05），双歧杆菌、乳酸杆菌含量高于常规组（P <0.05）。联合组治疗前后肠杆菌、双歧杆菌、乳酸杆菌含量的差值均大于常规组（P <0.05）。联合组治疗后GAS、MOT、VIP水平均低于常规组（P <0.05）。联合组治疗前后GAS、MOT、VIP水平的差值均大于常规组（P <0.05）。结论 双歧杆菌乳杆菌三联活菌片联合消旋卡多曲对儿童轮状病毒性腹泻疗效的影响较为显著。

Abstract:

Objective To investigate the clinical efficacy of Bifidobacterium Lactobacillus triple live tablets combined with racecadotril in children with rotavirus diarrhea.Methods A total of 120 pediatric patients with rotavirus-induced diarrhea admitted to the Chengdu Public Health Clinical Medical Center from June 2022 to June 2025 were selected as the study subjects. Using a simple randomization envelope drawing method, they were randomly divided into a routine group (n = 60) and a combination group (n = 60). The routine group received standard treatment, while the combination group received additional Bifidobacterium Lactobacillus triple live tablets and racecadotril. Clinical efficacy, symptom improvement, immune indicators [immunoglobulin A (IgA), IgG, IgM], intestinal flora composition, and gastrointestinal hormone [gastrin (GAS), motilin (MOT), and vasoactive intestinal peptide (VIP)] levels were compared between the two groups.Results The overall effective rate was significantly higher in the combination group than in the routine group (P < 0.05). The time to diarrhea cessation, vomiting cessation, fever abatement, and normalization of stool consistency were all shorter in the combination group (P < 0.05). After treatment, the levels of IgA, IgG, and IgM were significantly higher in the combination group than in the routine group (P < 0.05). The differences in IgA, IgG, and IgM levels before and after treatment were greater in the combination group than in the routine group (P < 0.05). After treatment, the content of Enterobacteriaceae was significantly lower in the combination group (P <0.05), while the contents of Bifidobacterium and Lactobacillus were significantly higher in the combination group compared to the routine group (P < 0.05). The differences in Enterobacteriaceae, Bifidobacterium, and Lactobacillus contents before and after treatment were greater in the combination group than in the routine group (P < 0.05). After treatment, the levels of GAS, MOT, and VIP were significantly lower in the combination group than in the routine group (P < 0.05). The differences in GAS, MOT, and VIP levels before and after treatment were greater in the combination group than in the routine group (P < 0.05).Conclusion Bifidobacterium Lactobacillus triple live tablets combined with racecadotril exert a significant therapeutic effect on rotavirus diarrhea in children.