肌醇联合芬吗通对多囊卵巢综合征不孕患者疗效的影响研究

Effect of inositol combined with femoston on the efficacy in infertile patients with polycystic ovary syndrome

摘要:

目的 探究肌醇联合芬吗通对多囊卵巢综合征（PCOS）不孕患者的影响。方法 选取2023年1月—2025年1月邯郸市第一医院纳入的120例PCOS不孕患者作为研究对象，按信封抽签法随机分为肌醇组与联合组，每组60例。肌醇组给予肌醇治疗，联合组给予肌醇联合芬吗通治疗。比较两组治疗后的临床疗效、卵巢体积、卵泡数量、子宫内膜厚度、性激素水平、卵巢血流动力学、不良反应、排卵及妊娠情况。结果 联合组的治疗总有效率高于肌醇组（P <0.05）。联合组治疗后的卵巢体积、卵泡数量均低于肌醇组，子宫内膜厚度大于肌醇组（P <0.05）；联合组治疗前后卵巢体积、卵泡数量、子宫内膜厚度的差值均大于肌醇组（P <0.05）。联合组治疗后促黄体生成素（LH）、孕酮（P）、促卵泡激素（FSH）水平均低于肌醇组（P <0.05）；联合组治疗前后LH、P、FSH的差值均大于肌醇组（P <0.05）。联合组治疗后的收缩期峰值流速（PSV）高于肌醇组（P <0.05），搏动指数（PI）、阻力指数（RI）均低于肌醇组（P <0.05）；联合组治疗前后PSV、PI、RI的差值均大于肌醇组（P <0.05）。两组不良反应发生率比较，差异无统计学意义（P >0.05）。联合组的排卵率、妊娠率高于肌醇组（P <0.05）。结论 肌醇联合芬吗通对PCOS不孕患者疗效的影响较显著。

Abstract:

Objective To investigate the effects of inositol combined with Femoston on infertile patients with polycystic ovary syndrome (PCOS).Methods A total of 120 infertile patients with PCOS admitted to Handan First Hospital from January 2023 to January 2025 were selected and randomly divided into an inositol group (n = 60) and a combination group (n = 60) using the envelope drawing method. The inositol group received inositol treatment, while the combination group was treated with inositol combined with Femoston. Clinical efficacy, ovarian volume, follicle count, endometrial thickness, sex hormone levels, ovarian hemodynamics, adverse reactions, ovulation, and pregnancy outcomes after treatment were compared between the two groups.Results The total effective rate in the combination group was higher than that in the inositol group (P < 0.05). After treatment, the ovarian volume and follicle count in the combination group were lower than those in the inositol group, while the endometrial thickness was greater (P < 0.05). The changes in ovarian volume, follicle count, and endometrial thickness from before to after treatment were greater in the combination group than in the inositol group (P < 0.05). After treatment, the levels of luteinizing hormone (LH), progesterone (P), and follicle-stimulating hormone (FSH) in the combination group were lower than those in the inositol group (P < 0.05). The changes in LH, P, and FSH levels from before to after treatment were greater in the combination group than in the inositol group (P < 0.05). After treatment, the peak systolic velocity (PSV) in the combination group was higher than that in the inositol group (P < 0.05), while the pulsatility index (PI) and resistance index (RI) were lower (P < 0.05). The changes in PSV, PI, and RI from before to after treatment were greater in the combination group than in the inositol group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). The ovulation rate and pregnancy rate in the combination group were higher than those in the inositol group (P < 0.05).Conclusion The combination of inositol and Femoston has significant effects in infertile patients with PCOS.