Abstract:Objective To investigate the effects of a combination of tiapride and psychotherapy on the psychological state and self-awareness of children with tic disorder.Methods A total of 98 children with tic disorder admitted to The First People's Hospital of Lianyungang between December 2021 and December 2024 were selected. The patients were divided into a tiapride group and a combined therapy group, with 49 cases in each group. The tiapride group received tiapride treatment, whilst the combined therapy group received tiapride plus psychotherapy. The two groups were compared in terms of general characteristics, clinical efficacy, psychological state, tic severity and self-awareness.Results The overall response rate was higher in the combined therapy group than in the tiapride group (P < 0.05). The differences in MSNSS and HADS scores before and after treatment were greater in the combined therapy group than in the tiapride group (P < 0.05). The differences in motor tic, vocal tic, and total scores of the YGTSS before and after treatment were greater in the combined therapy group than in the tiapride group (P < 0.05). The differences in behavioral adjustment, popularity, anxiety, physical appearance and attributes, happiness and satisfaction, and intellectual and school status scores of the PHCSS before and after treatment were greater in the combined therapy group than in the tiapride group (P < 0.05).Conclusion The combination of tiapride and psychotherapy has a significant effect on the psychological state and self-awareness of children with tic disorder.