奥赛利定与舒芬太尼用于无痛胃肠镜检查的镇静效果及安全性比较

Comparison of sedative effects and safety between oliceridine and sufentanil for painless gastrointestinal endoscopy

摘要:

目的 比较奥赛利定与舒芬太尼在无痛胃肠镜检查中的镇静效果与安全性。方法 选取2025年8月—2025年12月在无锡市第五人民医院接受无痛胃肠镜治疗检查的150例患者，按1∶1比例随机分为试验组（奥赛利定复合丙泊酚）和对照组（舒芬太尼复合丙泊酚），各75例。对比两组的镇静效果［改良观察者的警觉/镇静评分量表（MOAA/S）］、丙泊酚用量、苏醒时间、离室时间、疼痛状况［非插管患者行为疼痛量表（BPS-NI）］、认知功能［简易精神状态检查（MMSE）］，入室时（T₀）、意识消失时（T₁）、胃肠镜置入时（T₂）、检查结束时（T₃）、苏醒时（T₄）的生命体征［平均动脉压（MAP）、血氧饱和度（SpO₂）、心率（HR）］，检查后第1天的恢复状况［恢复质量量表-15（QoR-15）评分］、患者及内镜医师满意率，以及患者不良反应发生情况。结果 试验组与对照组MOAA/S评分、丙泊酚用量、苏醒时间和BPS-NI评分比较，差异均无统计学意义（P 0.05）。试验组离室时间短于对照组（P 0.05）。试验组出恢复室时MMSE评分高于对照组（P 0.05）；试验组T₁时SpO₂高于对照组（P 0.05）；检查后24 h的QoR-15评分中，试验组疼痛、生理功能、身体舒适度评分和总分均高于对照组（P 0.05），情绪状态评分低于对照组（P 0.05）。试验组患者和内镜医师满意率均高于对照组（P 0.05）；试验组检查中呼吸抑制和检查后的恶心呕吐发生率低于对照组（P 0.05）。结论 奥赛利定用于无痛胃肠镜检查可缩短离室时间，改善术后早期认知功能与整体恢复质量，提高满意率，减少不良反应，具有较好的临床应用价值。

Abstract:

Objective To compare the effects of oliceridine and sufentanil on sedation efficacy and safety during painless gastroscopy and colonoscopy.Methods A total of 150 patients who underwent painless gastroscopy and colonoscopy at Wuxi Fifth People's Hospital from August 2025 to December 2025 were selected and randomly divided into an experimental group (oliceridine anesthesia) and a control group (sufentanil anesthesia) at a 1:1 ratio, with 75 cases in each group. The two groups were compared in terms of sedation efficacy [Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score], propofol dosage, emergence time, discharge time from the post-anesthesia care unit (PACU), pain status [Behavioral Pain Scale for Non-Intubated Patients (BPS-NI) score], cognitive function [Mini-Mental State Examination (MMSE) score], vital signs [mean arterial pressure (MAP), oxygen saturation (SpO₂), heart rate (HR) ] at the time of entering the room (T₀), loss of consciousness (T₁), endoscope insertion (T₂), end of examination (T₃), and awakening (T₄), recovery status on the first day after examination [Quality of Recovery-15 (QoR-15) score], satisfaction rates of patients and endoscopists, and the incidence of adverse reactions.Results No statistically significant differences were found between the experimental group and the control group in MOAA/S scores, propofol dosage, emergence time, and BPS-NI scores according to t-tests (P 0.05). The discharge time from the PACU was shorter in the experimental group than in the control group (P 0.05). The MMSE score upon PACU discharge was higher in the experimental group than in the control group (P 0.05). At T1, SpO₂ was higher in the experimental group than in the control group (P 0.05). In the QoR-15 scores at 24 hours post-examination, the experimental group showed higher scores for pain, physical independence, physical comfort, and total score compared to the control group (P 0.05), while the emotional state score was lower than that of the control group (P 0.05). The satisfaction rates of both patients and endoscopists were higher in the experimental group than in the control group (P 0.05). The incidences of intraoperative respiratory depression and postoperative nausea and vomiting were lower in the experimental group than in the control group (P 0.05).Conclusion The use of oliceridine in painless gastroscopy and colonoscopy can shorten the discharge time from the PACU, improve early postoperative cognitive function and overall quality of recovery, enhance satisfaction rates, and reduce adverse reactions, demonstrating good clinical application value.