一次性与多次法根管治疗对慢性牙髓炎的疗效比较

Comparison of clinical efficacy between single-visit root canal therapy and multiple-visit root canal therapy in patients with chronic pulpitis

摘要:

目的 比较一次性根管治疗与多次法根管治疗对慢性牙髓炎的临床疗效。方法 选取2023年1月—2026年2月上海市第七人民医院口腔科收治的102例慢性牙髓炎患者，采用随机数字表法分为对照组（多次法）与观察组（一次性法），各51例。比较两组的临床疗效、血清炎症因子［肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-8（IL-8）］水平、相关评分［口腔健康影响程度量表（OHIP-14）评分、视觉模拟疼痛法（VAS）评分］，以及治疗期间的不良反应发生情况。结果 观察组总有效率高于对照组（P 0.05）。观察组治疗后TNF-α、CRP和IL-8水平均低于对照组（P 0.05）；同组内，治疗后TNF-α、CRP和IL-8水平均低于治疗前（P 0.05）。观察组治疗后OHIP-14评分、VAS评分均低于对照组（P 0.05）；同组内，治疗后OHIP-14评分、VAS评分均低于治疗前（P 0.05）。观察组不良反应总发生率比较，差异无统计学意义（P 0.05）。结论 一次性根管治疗对慢性牙髓炎的临床疗效更优，能更有效地降低患者血清炎症因子水平，改善口腔健康相关生活质量，缓解疼痛。

Abstract:

Objective To evaluate the clinical efficacy of two root canal therapies for chronic pulpitis.Methods A total of 102 patients with chronic pulpitis admitted to our hospital between January 2023 and February 2026 were randomly split into two groups of 51 cases each: the control group received multiple-visit root canal therapy, and the observation group single-visit root canal therapy. Clinical efficacy, serum levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-8 (IL-8), Oral Health Impact Profile-14 (OHIP-14) score, and visual analogue scale (VAS) score were compared before and after treatment. Adverse reactions were also recorded during treatment.Results The total effective rate of the observation group was higher than that of the control group (P 0.05). The levels of TNF-α, CRP, and IL-8 in the observation group were lower than those in the control group after treatment (P 0.05); within each group, the levels of TNF-α, CRP, and IL-8 were lower after treatment than before treatment (P 0.05). The post-treatment scores of OHIP-14 and VAS in the observation group were lower than those in the control group (P 0.05); within each group, the post-treatment scores of OHIP-14 and VAS were lower than the pre-treatment scores (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05).Conclusion Single-visit root canal therapy achieves better clinical efficacy in chronic pulpitis. It reduces serum inflammatory factor levels more effectively, relieves pain, and improves oral health-related quality of life compared with multiple-visit root canal therapy.