纳米碳酸钙驱铅效果研究

Therapeutic effect of calcium carbonate nanoparticle on lead poisoning

摘要:

探讨纳米碳酸钙的驱铅效果。方法实验药物纳米碳酸钙（40～80 nm），采用超重力反应沉淀法复制。4周龄大鼠连续14 d饮用醋酸铅溶液被复制成重度铅中毒模型（血铅浓度达到>500μg/L）。原子吸收光谱法检测大鼠血铅浓度。结果给药22 d 后，纳米碳酸钙40~80 nm组的血铅平均浓度为（117±7）μg/L，接近正常血铅水平，低于对照组的平均血铅浓度（297±33）μg/L（ <0.05）。结论纳米碳酸钙（40～80 nm）具有较好的驱铅效果，优于自然排铅。

Abstract:

To evaluate the therapeutic effects of calcium carbonate nanoparticle. Methods Calcium carbonate nanoparticle with 40~80 nanometers was prepared by high gravity reaction precipitation. The severe level of lead-poisoning model (estimated blood lead concentration of 500 μg/L or above) was made in 4 weeks old rats through 14 days consecutively drinking lead acetate solution. The drug efficacy was estimated by the concentration of blood lead. Results After three weeks of drug administration, the average concentration of blood lead in calcium carbonate nanoparticle group was (117 ±7) μg/L, which was closed to the normal blood lead, and was lower than that of the untreated group (p < 0.05). The mean level of blood lead concentration of untreated group was (297 ±33) μg/L, which was a moderate lead poisoning level. Conclusions Calcium car-bonate nanoparticle with size from 40 to 80 nm displays high efficiency of lead-out effect and is better than natural lead removal.