中性粒细胞胞外陷阱在卵巢癌中的作用与机制研究进展

Research progress on the role and mechanism of neutrophil extracellular traps in ovarian cancer

摘要:

中性粒细胞胞外陷阱（NETs）是一种具有捕获和消灭病原体功能的复杂纤维网状结构，由DNA染色质和多种颗粒蛋白构成。正常情况下，NETs能够清除病原体起到防御作用，NETs功能失调时可改变免疫微环境，推动疾病的发生、发展。近年来研究发现，NETs在卵巢癌（OC）中起到关键作用，该文围绕NETs形成机制、诊断与预后评估生物标志物、NETs在卵巢癌肿瘤免疫微环境（TIME）、转移前生态位形成（PMN）、血栓形成等方面的作用机制展开论述，阐明NETs对卵巢癌病程进展的关键作用，为卵巢癌的研究和治疗思路提供依据。

Abstract:

Neutrophil extracellular traps (NETs) are complex fibrous networks composed of DNA chromatin and various granule proteins that capture and eliminate pathogens. Under normal circumstances, NETs can clear pathogens and play a defensive role. When NET function is dysregulated, NETs can alter the immune microenvironment and promote the occurrence and development of diseases. Recent studies have found that NETs play a key role in ovarian cancer (OC). This article discusses the mechanisms of NET formation, biomarkers for diagnosis and prognostic assessment, and the roles of NETs in the tumor immune microenvironment (TIME), pre-metastatic niche (PMN) formation, and thrombosis in ovarian cancer, clarifying the key role of NETs in the progression of ovarian cancer and providing a basis for ovarian cancer research and treatment.