中医药调控Wnt/β-catenin信号通路在卵巢癌治疗中的研究进展

Research progress on regulating Wnt/β-catenin signaling pathway in the treatment of ovarian cancer using traditional Chinese medicine

摘要:

卵巢癌（OC）是所有妇科恶性肿瘤中病死率最高的疾病，而上皮性卵巢癌（EOC）占所有卵巢恶性肿瘤的80%～90%。Wnt/β-catenin信号通路在肿瘤发生、复发、转移、耐药和肿瘤干性维持中起着至关重要的作用。异常激活的Wnt/β-catenin信号通路能够促进卵巢癌细胞增殖、迁移与侵袭，诱导耐药等。中医药通过多靶点多途径调控Wnt/β-catenin信号通路在治疗卵巢癌中发挥显著优势。中药单体如酚类、萜类、酮类、生物碱类、皂苷类等化合物，中药复方如扶正抗癌汤、理冲汤能够抑制癌细胞增殖迁移，提高对化疗药物的敏感性，延缓卵巢癌病理进展。该文通过综述中医药介导Wnt/β-catenin信号通路治疗卵巢癌的研究，以期为卵巢癌新药研发和临床应用提供思路。

Abstract:

Ovarian cancer is one of the leading causes of mortality among all gynecological malignancies, with epithelial ovarian cancer accounting for 80%-90% of all ovarian malignancies. The Wnt/β-catenin signaling pathway plays a crucial role in tumorigenesis, recurrence, metastasis, drug resistance, and the maintenance of tumor stemness. Aberrant activation of the Wnt/β-catenin signaling pathway can promote ovarian cancer cell proliferation, migration, and invasion, and induce drug resistance. Traditional Chinese medicine (TCM) has demonstrated significant advantages in the treatment of ovarian cancer by regulating the Wnt/β-catenin signaling pathway through multiple targets and pathways. TCM-derived compounds such as phenols, terpenes, ketones, alkaloids, and saponins, as well as TCM formulas such as Fuzheng Kangai Decoction and Lichong Decoction, can inhibit cancer cell proliferation and migration, enhance sensitivity to chemotherapeutic drugs, and delay pathological progression in ovarian cancer. This article reviews studies on TCM treatment of ovarian cancer through modulation of the Wnt/β-catenin signaling pathway, aiming to provide insights for new drug development and clinical application in ovarian cancer.