子宫动脉血流参数联合血清PLGF、sUAR对子痫前期的诊断效能分析

Analysis of the diagnostic efficacy of uterine artery doppler parameters combined with serum PLGF and sUAR ratio for preeclampsia

摘要:

目的 探究子宫动脉血流参数联合血清胎盘生长因子（PLGF）、血清尿酸/白蛋白比值（sUAR）对子痫前期（PE）的诊断效能。方法 选取2024年5月—2025年7月在昌吉回族自治州人民医院产检的80例PE患者作为PE组，另选取同期50例正常妊娠者作为对照组。所有研究对象均行子宫动脉多普勒超声检查，并检测血清PLGF及sUAR。采用多因素一般Logistic回归模型分析PE的影响因素并构建列线图。绘制受试者工作特征（ROC）曲线分析子宫动脉血流参数联合血清PLGF、sUAR对PE的诊断效能。结果 PE组的搏动指数（PI）、阻力指数（RI）、收缩期峰值流速/舒张末期流速比值（S/D）均高于对照组（P <0.05）。PE组的血清PLGF水平低于对照组，sUAR水平高于对照组（P <0.05）。多因素一般Logistic回归分析结果表明，PI高［O^R =2.950（95% CI：1.122，7.814）］、RI高［O^R =2.333（95% CI：1.065，5.133）］、S/D高［O^R =4.628（95% CI：1.912，11.199）］、PLGF低［O^R =0.201（95% CI：0.011，0.444）］、sUAR高［O^R =4.122（95% CI：1.599，11.02）］均为发生PE的危险因素（P <0.05）。ROC曲线分析结果显示，子宫动脉血流参数联合血清PLGF、sUAR的联合模型诊断PE的曲线下面积为0.976（95% CI：0.955，1.000），敏感性为95.6%（95% CI：0.916，0.979），特异性为94.6%（95% CI：0.835，0.989）。结论 子宫动脉血流参数联合血清PLGF、sUAR对PE具有较高的诊断效能。

Abstract:

Objective To investigate the diagnostic efficacy of uterine artery hemodynamics combined with serum placental growth factor (PLGF) and uric acid/albumin ratio (sUAR) in pregnant women with preeclampsia (PE).Methods A total of 80 PE patients treated at Changji Hui Autonomous Prefecture People's Hospital from May 2024 to July 2025 were selected as the PE group, and 50 women with normal pregnancies during the same period were selected as the control group. All subjects underwent uterine artery hemodynamic examinations and serum PLGF and sUAR level measurements. Logistic regression analysis was used to identify influencing factors for PE and to construct a nomogram. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic efficacy of uterine artery hemodynamics combined with serum PLGF and sUAR levels for PE.Results The pulsatility index (PI), resistance index (RI), and systolic/diastolic velocity ratio (S/D) in the PE group were significantly higher than those in the control group (P < 0.05). Serum PLGF levels were lower, and sUAR levels were higher in the PE group compared to the control group (P < 0.05). Logistic regression analysis, with PE as the dependent variable, showed that elevated PI [O^R = 2.950 (95% CI: 1.122, 7.814) ], elevated RI [O^R = 2.333 (95% CI: 1.065, 5.133) ], elevated S/D [O^R = 4.628 (95% CI: 1.912, 11.199) ], decreased PLGF [O^R = 0.201 (95% CI: 0.011, 0.444) ], and elevated sUAR level [O^R = 4.122 (95% CI: 1.599, 11.02) ] were all risk factors for developing PE (P < 0.05). The ROC curve demonstrated that the combination of uterine artery hemodynamic parameters with serum PLGF and sUAR levels achieved an AUC value of 0.976, with a sensitivity of 95.6% (95% CI: 0.916, 0.979) and a specificity of 94.6% (95% CI: 0.835, 0.989).Conclusion The combination of uterine artery hemodynamics with serum PLGF and sUAR demonstrates significant diagnostic value for preeclampsia in pregnant women.