益肾接骨汤对老年髋部骨折患者骨代谢的调节作用

Effects of Yishen Jiegu Decoction on bone metabolism in elderly patients with hip fractures

摘要:

目的 探讨益肾接骨汤对老年髋部骨折患者骨代谢的调节作用。方法 选取2023年5月—2025年5月佳木斯市中医医院收治的98例老年髋部骨折患者，采用随机数字表法分为观察组和对照组，各49例。对照组采用内固定手术及常规西药治疗，观察组在对照组基础上另给予益肾接骨汤治疗。两组均持续治疗3个月。比较两组患者临床疗效、髋关节功能、骨代谢指标、骨生长因子及不良反应。结果 治疗3个月后，观察组总有效率高于对照组（P <0.05）。观察组治疗前后髋关节功能评分差值大于对照组（P <0.05）。观察组血清骨钙素、骨保护素、骨特异性碱性磷酸酶、Ⅰ型胶原C端交联肽、Ⅰ型原胶原C端前肽治疗前后差值均大于对照组（P <0.05）。观察组血清骨形态发生蛋白、转化生长因子β1、碱性成纤维细胞生长因子治疗前后差值均大于对照组（P <0.05）。两组不良反应发生率比较，差异无统计学意义（P >0.05）。结论 益肾接骨汤用于治疗老年髋部骨折疗效确切，可改善髋关节功能，调节骨代谢指标及骨生长因子，安全可靠。

Abstract:

Objective To explore the regulatory effect of Yishen Jiegu Decoction on bone metabolism in elderly patients with hip fractures.Methods A total of 98 elderly patients with hip fractures admitted to Jiamusi Hospital of Traditional Chinese Medicine from May 2023 to May 2025 were selected and randomly divided into the observation group and the control group, with 49 cases in each group. The control group was treated with internal fixation and conventional Western medicine, whereas the observation group received additional treatment with the Yishen Jiegu Decoction on the basis of the control group treatment. Both groups of patients received continuous treatment for 3 months. The clinical efficacy, hip joint function, bone metabolism indicators, bone growth factors and adverse reactions of the two groups of patients were compared.Results After three months of treatment, the total effective rate of the observation group was higher than that of the control group (P < 0.05). The difference in hip joint function scores before and after treatment in the observation group was greater than that in the control group (P < 0.05). The differences in serum osteocalcin, osteoprotegerin, bone alkaline phosphatase, C-terminal cross-linking telopeptide of type I collagen, procollagenⅠ C-terminal propeptide before and after treatment in the observation group were all higher than those in the control group (P < 0.05). The differences in serum bone morphogenetic protein, transforming growth factor-β1, and basic fibroblast growth factor before and after treatment in the observation group were all higher than those in the control group (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions in both groups (P > 0.05).Conclusion Yishen Jiegu Decoction has a definite therapeutic effect on elderly patients with hip fractures. It can improve hip joint function, regulate bone metabolism indicators and bone growth factors, with a favorable safety profile.