Abstract:Maxillary transverse deficiency (MTD) is a common malocclusion in children and adolescents, and rapid maxillary expansion (RME) is a principal early treatment. This article summarizes recent studies on the remodeling of maxillofacial hard and soft tissues, teeth, periodontal tissues, the nasal airway, and the temporomandibular joint after RME. Most studies indicate that RME effectively opens the midpalatal suture and increases the widths of the maxillary base and posterior dental arch. After RME, facial soft-tissue changes are limited to slight widening of the alar base, with no obvious adverse changes in lip morphology or facial profile. RME also increases nasal cavity volume and improves nasal ventilation. Overall, RME in growing patients has a favorable prognosis and controllable adverse effects; it can correct skeletal deformities while improving facial aesthetics, oral function, and nasal ventilation and is a reliable early treatment for MTD.